Ketamine
Administration
•Initial dose: 1-2 mg/kg IV slow push
•CI: 0.5-7.5 mg/kg/hr
•Titrate by 0.5 mg/kg/hr every 10 minutes
Consideration
•Maximal effect in 1 minute
•Hepatic metabolism to active metabolite norketamine
•Favorable hemodynamic effects
•Minimal respiratory effects
Adverse Effects
•Agitation with auditory and visual hallucinations
•Conscious vivid dreams
•Increased intracranial pressure
•Tachyarrhythmias
•Hypersalivation