Midazolam
Administration
•Initial dose: 0.2 mg/kg; administer at an infusion rate of 2 mg/min
•CI: 0.05-2 mg/kg/hr
•Breakthrough status epilepticus (SE): 0.1-0.2 mg/kg bolus, increase CI rate by 0.05-0.1 mg/kg/hr every 3-4 hours
Consideration
•Tachyphylaxis occurs after prolonged use
•Active metabolite, renally eliminated, rapid redistribution (short duration)
•Does not contain propylene glycol
Adverse Effects
•Respiratory depression
•Hypotension