Propofol
Administration
•Initial dose: start at 20 mcg/kg/min, with 1-2 mg/kg loading dose
•CI: 30-200 mcg/kg/min
•Breakthrough SE: Increase CI rate by 5-10 mcg/kg/min every 5 min or 1 mg/kg bolus plus CI titration
Consideration
•When administering high doses (>80 mcg/kg/min) for extended periods of time (i.e. >48h)
•Peds: with doses >65 mcg/kg/min; contraindicated in young children •Requires mechanical ventilation
•Must adjust daily caloric intake (1.1 kcal/ml)
Adverse Effects
•Hypotension (especially with loading dose in critically ill patients)
•Respiratory depression
•Cardiac failure
•Rhabdomyolysis
•Metabolic acidosis
•Renal failure (propofol related infusion syndrome)