•Initial dose: start at 20 mcg/kg/min, with 1-2 mg/kg loading dose •CI: 30-200 mcg/kg/min •Breakthrough SE: Increase CI rate by 5-10 mcg/kg/min every 5 min or 1 mg/kg bolus plus CI titration
•When administering high doses (>80 mcg/kg/min) for extended periods of time (i.e. >48h) •Peds: with doses >65 mcg/kg/min; contraindicated in young children •Requires mechanical ventilation •Must adjust daily caloric intake (1.1 kcal/ml)
Adverse Effects
•Hypotension (especially with loading dose in critically ill patients) •Respiratory depression •Cardiac failure •Rhabdomyolysis •Metabolic acidosis •Renal failure (propofol related infusion syndrome)