Length of segments involved
Short peripheral lesions in dorsal/lateral columns
Post contrast pattern: Ring like, homogeneous. T2 white matter hyperintensity <2 segments and <50% diameter.
Acute/subacute with contrast enhancement and chronic/progressive/fluctuating with T2 and T1 changes
Dissemination in space and time; meeting McDonald Criteria
Cervical or thoracic spine along with lesions in brain